The list below includes factors to consider. Before trying something new, its common to look for written reviews about the experiences of others. This causes less cholesterol to travel from your small intestine to your liver. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. Cholesterol is a fatty substance found in the cells of your body. Memory loss isnt a side effect of Zetia. If youre experiencing hair loss while using Zetia, talk with your doctor. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. Theyll guide you on the safest treatment options for you. The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. joint pain *. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. (For information on side effects, see the Zetia side effects section above.). The expiration date helps guarantee that the medication is effective during this time. These drugs havent been directly compared in clinical studies. If you use Zetia and warfarin together, your doctor may want to monitor you more closely during your treatment. Ezetimibe may be used alone or with other drugs (such as "statins" or . Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. Side effects of Lipitor and Zetia that are similar include diarrhea and joint pain. Zetia is also available in a generic form called ezetimibe. It wasnt reported during studies of the drug. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. sinusitis. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. Talk with your doctor to learn more about which medications are right for you. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. There arent any foods that have been specifically reported to interact with Zetia. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. After first three days stopped it for two days. Talk with your doctor if you have questions about using Zetia to lower your triglyceride levels. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. . People who may be at higher risk of this side effect include those who: Tell your doctor if any of the above apply to you before starting Zetia treatment. Get emergency medical help if you have signs of an allergic reaction to Zetia: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Currently, no medications have been approved by the FDA to treat POTS. All rights reserved. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. Forget HDL and LDL. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. Taking Zetia with cyclosporine (a drug that suppresses your immune system) can raise the levels of both medications in your body. (A drug class is a group of medications that work in a similar way.) Is the ketogenic diet right for autoimmune conditions? Talk with your doctor about the risks of taking Zetia with warfarin. If youre concerned about joint pain while using Zetia, talk with your doctor. However, animal studies dont always predict what will happen in humans. Ezetimibe can cause the breakdown of muscle tissue . Below are medications that can interact with Zetia. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. A generic drug is an exact copy of the active drug in a brand-name medication. But its not clear whether this side effect occurred in studies. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. Zetia is metabolized in the small intestine and liver. We've provided a list of the best at-home tests for. Zetia is meant to be used as a long-term treatment. They are caused by deficiencies in enzymes involved in the synthesis of heme. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Also tell them about any vitamins, herbs, and supplements you use. For most people, CoQ10 isnt a harmful or dangerous supplement. If left untreated, it can cause your kidneys to stop working properly. To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). Zetia can cause muscle-related side effects. . Do my other medications increase my risk of side effects with Zetia? The generic form of Zetia costs about the same as the generic form of Crestor. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). High cholesterol occurs when you have more cholesterol in your blood than your body needs. trouble in swallowing. Zetia can cause certain side effects, some of which are more common than others. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. Cholesterol is made naturally in your liver. Sometimes brain zaps are also accompanied by dizziness, pain, or tinnitus, a ringing in the ears. Nexlizet (bempedoic acid/ezetimibe) is a prescription tablet used to lower LDL (bad) cholesterol in certain people. It can develop suddenly or gradually over time. Zetia contains the active drug ezetimibe. What causes POTS? Weight gain isnt a side effect reported in clinical studies of Zetia. An increase in levels of liver enzymes doesnt usually cause any symptoms. dark colored urine. Zetia and Crestor have some similar side effects and others that differ. Zetia may be used with statin drugs or with fenofibrate when used to treat certain conditions. Risk factors for muscle-related problems. But if they become more severe or dont go away, talk with your doctor or pharmacist. This makes it difficult to keep an upright posture without abnormal heart-rate (tachycardia) and/or sympathetic activity. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. What are the serious side effects of Zetia? The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. Bock's fainting spells are one of the hallmarks of POTS. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. Zetia comes as a tablet that you swallow. Read More. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. Use of the terms male and female in this article refers to sex assigned at birth. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. Get medical help right away, if you have any of the symptoms listed above. An allergic reaction is possible after using Zetia. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. diarrhea*. So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. Lipitor is part of the statin drug class. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). Cholestyramine (Prevalite) is a drug used to treat high cholesterol. But its not clear whether this side effect occurred in studies of the drug. There arent any herbs or supplements that have been specifically reported to interact with Zetia. In studies, some people had to stop taking Zetia because of this side effect. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. Our website services, content, and products are for informational purposes only. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Grapefruit can prevent the breakdown of these drugs in your body. If your doctor recommends that you stop taking Zetia, they may suggest another treatment option for your condition. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. Allergic reaction. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. To help make sure you dont miss a dose, try setting a reminder on your phone. When this happens, more cholesterol can then be cleared from your blood by your liver. Learn more about some of the side effects that Zetia may cause. Zetia does not cause an increase or a decrease in blood pressure. Most of Zetias side effects should go away within a few days or weeks. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. Zetia is primarily cleared from the body through fecal excretion. For more information on these side effects, see Side effect details below. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. (A class of drugs is a group of medications that work in a similar way.) In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. For those who aren't familiar with POTS, it is an often-disabling neurological condition that causes your heart rate to rise a great deal when you are upright, and often blood pressure drops when you are upright (when it should be rising), and it causes fainting, fatigue, headache, nausea, face and hand tingling, and blood pooling in legs. Taking Zetia with a statin may cause this side effect. However, if youre taking Zetia with a statin drug, youll need to avoid eating grapefruit or drinking grapefruit juice. See the Zetia prescribing information for details. They may have suggestions depending on your weight and health goals. Lying down on the bed, and raising your legs. Liver problems. Increased liver enzyme levels are a possible side effect of Zetia. I take pravastatin 80mg with absolutely no problem. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. See the Mild side effects and Serious side effects sections above for more information. POTS is commonly associated with low levels of fluid. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. Medications in this class prevent your small intestine from absorbing cholesterol. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. These include: Note: For more information about the potential negative effects of Zetia, see the Zetia side effects section above. If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. muscle pain while taking ezetimibe with a statin. Zetia is a brand-name drug that contains the active drug ezetimibe. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. There are no known interactions between Zetia and alcohol. However, side effects are generally mild and go away as the body adjusts to the medication. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. What foods should I avoid while taking Zetia. Zetia generally costs more than Crestor. Other interactions can increase side effects or make them more severe. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. Ways to reduce the symptoms. The dosage is the same for all approved uses. Zetia is contraindicated under the following conditions: Zetia tablets should be stored at a room temperature of 77F (25C) in a tightly sealed container away from light. Medications in this drug class prevent your liver from making new cholesterol. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about the change in her physical appearance. Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. Learn about the common, mild, and serious side effects it can cause and how to manage them. Zetias side effects are usually mild, especially if youre taking Zetia alone. Most of these side effects may go away within a few days or a couple of weeks. Crestor is available in a generic form called rosuvastatin. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). It belongs to a class of drugs called cholesterol absorption inhibitors. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. It can develop suddenly or maybe over time. Ask your doctor what other medications are better options for you. In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. pain in your arms or legs. Before taking Zetia, talk with your doctor and pharmacist. You may also have muscle cramps, spasms, or stiffness. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. They may want to select a different treatment option for you. (For more information on the specific conditions Zetia can treat, see the Zetia uses section.). . Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. It's Aimee Esther here! Postural Orthostatic Tachycardia Syndrome (POTS) is a blood flow disorder that causes a sudden spike in heartbeat with no change in blood pressure when going from a horizontal or seated to a standing position. voice changes. stomach pain. This can raise your levels of these drugs and increase your risk of side effects. What is considered high cholesterol? Nearly two years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome, or POTS. But its possible that some side effects may continue to affect you for as long as youre taking the medication. They may also check you for signs of muscle breakdown or kidney damage. Your doctor will likely start you on the typical dosage approved to treat your condition. During your Zetia treatment, consider keeping notes on any side effects youre having. Its not known if Zetia is safe to take during pregnancy. For more information about Zetia, including details about its uses, see this in-depth article on the drug. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. How long a medication remains good can depend on many factors, including how and where you store the medication. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. The phase IV clinical study analyzes which people take Zetia and have Constipation. It can cause mild side effects and, less commonly, serious side effects. Brain fog. Cardiology 33 years experience. Its a place where people with certain conditions can find support and connect with others. Porphyria patients are often overly sensitive to sunlight. Typical symptoms of POTS include: heart palpitations (feeling your heart beating or racing) dizziness or lightheadedness. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. (2018). * For these purposes, Zetia and Crestor are used to treat people of different ages. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. POTS-related fatigue is physical in nature . Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. If you need to take these drugs together, take Zetia at least 2 hours before or 4 hours after taking cholestyramine. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. But new medications can help lower cholesterol and improve heart health. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. People with this condition have high levels of LDL (bad) cholesterol. Instead, it belongs to a class of drugs called cholesterol absorption inhibitors. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. In most cases, these side effects should be temporary. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. The safest treatment options for you transport of intestinal cholesterol to the nearest emergency right... 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